It is best not to use retinoic acid cream during preparation for pregnancy, as it may have pharmacotoxic effects on the fetus. Retinoic acid cream is teratogenic to animals during sensitive periods of pregnancy and has toxic effects on the fetus, and topical administration of retinoic acid medications may result in malformations, miscarriages, and fetal arrest. Therefore, if there is a plan to carry out the preparation for pregnancy, during the preparation period, try to minimize the exposure to items that are toxic to the fetus, and if you want to treat it, it is recommended to use less toxic drugs under the guidance of a doctor. If you are already on medication, it is recommended that you stop taking the medication for at least 3 months before preparing for pregnancy. Vitamin A cream should not be used on broken skin, not recommended for large areas, avoid contact with eyes and other mucous membrane areas. If there is any redness, swelling, rash or itching after using the medicine, it is necessary to stop using the medicine immediately and wash the local area clean, if necessary, please consult a doctor. Drugs need to be used under the guidance of a doctor, do not self-medication.