Are there specific medications available for migraine treatment? There are specific anti-migraine medications available, such as trimethoprim. These medications regulate the blood vessels, reduce the inflammation around the neurovascular area, reduce the headache and correspondingly reduce the symptoms of nausea and vomiting that accompany migraine. But each drug has a different effect on the individual patient! If one drug is not effective, it can be replaced by another drug. However, for migraine patients with a history of myocardial infarction or coronary artery disease, trimethoprim is contraindicated, as it can induce myocardial ischemia or even myocardial infarction. Ancestral medicine has a unique understanding of migraine and is increasingly playing a very good role in the eradication of migraine!