Uremia refers to the end stage of chronic renal failure, the cause of which is generally hypertensive nephropathy, diabetic nephropathy, primary glomerulonephritis and so on. 1. Hypertensive nephropathy: long-term hypertension leads to renal arteriolar vitellogenic changes, which in turn cause renal vascular ischemia, hypoxia, attracting inflammatory mediators infiltration, release of nephrotoxic cytokines, leading to renal injury, fibrosis, and ultimately cause uremia. 2. Diabetic nephropathy: many diabetic patients due to a long period of time, blood glucose is not well controlled, and eventually hurt the kidneys. Diabetic nephropathy is one of the microvascular complications of diabetes mellitus, and the damage to the renal small blood vessels caused by prolonged hyperglycemia will develop into uremia. 3. Primary glomerulonephritis: Glomerulonephritis renal parenchyma is damaged, resulting in the continuous destruction of renal units, so that the renal tubular mesangialization and fibrosis, renal units lose their function, and gradually evolve into uremia. There are many other causes of uremia, such as long-term use of non-steroidal anti-inflammatory drugs (ibuprofen), vasculitis renal damage, systemic lupus erythematosus nephritis, amyloidosis and so on. If you suffer from uremia, you should actively regular hospital consultation, standardized treatment under the guidance of physicians to delay life.