Taking tuberculosis medicine instead of coughing badly may be caused by irrational anti-tuberculosis drug treatment program, combined with bacterial infection or viral infection, etc., in accordance with the doctor’s instructions can change the anti-tuberculosis drug and program, take levofloxacin, acyclovir and other drugs treatment. 1. The irrationality of anti-tuberculosis drug treatment program: If the anti-tuberculosis drug used is not sensitive to the mycobacterium tuberculosis of the body, the mycobacterium tuberculosis of the body is resistant to the anti-tuberculosis drug used, which will lead to the condition of the disease not being improved and the cough aggravated after taking anti-tuberculosis drugs. Sputum culture, tuberculosis drug sensitivity test and other tests should be completed in time, and appropriate anti-tuberculosis drugs and programs should be changed. 2. Bacterial infection: when Mycobacterium tuberculosis is combined with bacterial infection, only the use of anti-tuberculosis drugs is not satisfactory. As bacterial infection will lead to worsening of cough, antibacterial drugs such as levofloxacin and amoxicillin should be used. 3. Viral infection: Mycobacterium tuberculosis combined with viral infection can also lead to cough aggravation, can use ribavirin, acyclovir and other antiviral drugs treatment. Taking tuberculosis drugs instead of coughing hard should go to the hospital in a timely manner to improve the examination, can not change the anti-tuberculosis drugs without authorization, after the cause of the disease is clear in the doctor’s guidance to give targeted treatment.