Heartburn is a common symptom of digestive system diseases, which cannot be relieved by a single action, and usually needs to be treated with medication. Heartburn refers to excessive secretion of gastric acid and insufficient gastrointestinal motility, which in turn stimulates the gastric mucosal cells, causing burning-like discomfort in the epigastric region, and is most commonly seen in digestive disorders with increased gastric acid, such as peptic ulcer, gastroesophageal reflux disease, gastritis, and so on. For the symptoms caused by these diseases, medication is usually the main treatment. Commonly used drugs include proton pump inhibitors that inhibit gastric acid secretion, such as omeprazole, pantoprazole, etc.; gastric mucosal protective agents, such as aluminum thioglycollate, misoprostol, etc.; and pro-gastrointestinal dynamics drugs, such as domperidone and mosapride. For the combination of Helicobacter pylori infection, also need to use quadruple therapy to remove Helicobacter pylori, commonly used with omeprazole + bismuth potassium citrate + amoxicillin, clarithromycin and so on. The specific treatment needs to be guided by the doctor after consulting the doctor. It is recommended to follow the doctor’s instructions to standardize the treatment, do not listen to biased prescriptions.