Low mean hemoglobin concentration and high platelet pressure are associated with bleeding, iron deficiency anemia, leukemia, etc., and further tests are needed to confirm the diagnosis. Low mean hemoglobin concentration and high platelet pressure are commonly associated with the following factors: 1. Bleeding: when the human body loses blood, it can cause low average hemoglobin concentration, and at the same time, because platelets have the function of hemostasis, so in order to stop bleeding, it will promote platelet generation and release, and platelet platelet pressure accumulation will appear temporarily high. 2. Iron deficiency anemia: in addition to the decrease of hemoglobin concentration, due to the compensatory proliferation of bone marrow, platelet pressure accumulation may be increased secondary to anemia. 3. Leukemia: after chemotherapy, patients with leukemia may have the phenomenon of bone marrow suppression such as reduction of platelets, white blood cells, hemoglobin concentration, etc. However, platelet pressure accumulation may be elevated after the body recovers, and hemoglobin concentration recovers slower, so that there is the phenomenon of one high and one low. The low average hemoglobin concentration and high platelet pressure may also be caused by other reasons, it is recommended to consult a doctor in time to clarify the cause of the disease, and under the guidance of the physician to carry out targeted treatment or therapy.