Multiple thyroid nodules with peripheral blood flow signals need to be evaluated in conjunction with other ultrasound findings and other tests, and it is difficult to confirm the need for treatment based on a single indicator. Thyroid nodules are usually detected on ultrasound of the neck, and multiple nodules are more common and mostly benign. Risk factors for malignancy in thyroid nodules include uneven internal echogenicity, poorly defined borders, abundant blood flow, and an aspect ratio greater than one. If only the periphery of a multinodular thyroid nodule shows blood flow, the nodule is not necessarily malignant. Patients need to combine with other ultrasound results to determine the benign or malignant nature of the nodule, and if necessary, perform a puncture biopsy to determine the benign or malignant nature of the nodule. If the nodule is diagnosed as benign and does not cause any discomfort, no treatment is needed and regular checkups are sufficient. If thyroid cancer is diagnosed, surgery is generally recommended. Patients are advised to seek medical advice in time and should consult their doctors for the test results.