Cephalosporin is a broad-spectrum antimicrobial agent that belongs to the β-lactam class. Before using cephalosporin, a skin test should be routinely performed, and if the test is positive, the drug cannot be administered, while if the test is negative, the drug can be administered slowly. In addition, it should be noted that cephalosporin should not be injected after drinking alcohol, because cephalosporin and alcohol are prone to serious allergic reactions, that is, disulfiram-like reactions, and can also easily lead to death of the patient. In addition, it should also be selected according to the results of pathogenesis, and the drugs should not be used blindly, because each drug is prone to side effects, and the common ones are liver and kidney damage, especially cefoperazone sulbactam sodium, which also easily complicates the increase of transaminase, abnormal liver function, and even serious ones may lead to abnormal coagulation mechanism in the body and induce the occurrence of bleeding events.