If you are E antigen positive chronic hepatitis B before taking the drug, ALT drops to normal, E antigen disappears, and E antibody is produced, and hepatitis B virus DNA is not detected, then consolidate the treatment for at least 3 years, during this period every 6 months to review, still remain the same can be considered to stop the drug observation. If the E antigen negative chronic hepatitis B, ALT to normal, surface antigen disappeared, hepatitis B virus DNA can not be detected can be discontinued for observation, patients with cirrhosis should be long-term use of drugs is not recommended to stop.