Increased creatinine represents the presence of hyperalgesia, which is commonly seen in chronic renal insufficiency, glomerulonephritis, hypertensive kidney damage, diabetic nephropathy, and IgA nephropathy. You can check the urine routine and urine protein quantification, and if necessary, improve the kidney puncture to clarify the diagnosis. For treatment, you can choose Bai Ling capsule to protect the kidney, urinary toxicity clear granules or renal failure Ning capsule, Haikun kidney hi capsule and other drugs to reduce creatinine. If blood pressure is high, CCB drugs such as amlodipine and nifedipine can be preferred; if blood lipid is high, atorvastatin can be chosen for treatment; if blood sugar is high, insulin is preferred for treatment. In addition to medication, diet requires low salt, low fat and high quality low protein diet as the principle, the daily salt intake should not exceed 6g, and protein intake should be meat, egg and milk high quality protein to avoid increasing the kidney burden. When creatinine exceeds 707umol/L or after serious complications of clinical treatment are not satisfactory, hemodialysis or peritoneal dialysis treatment is required.