It depends on the specific degree of creatinine elevation. Generally, when the compensatory stage is less than 177μmol/L, the situation is relatively good and patients need to intervene, basically, through diet and medication, a long-term stable level can be achieved. Once when creatinine enters the stage of renal failure or uremia, commonly 707μmol/L, it indicates that the kidney damage is very serious and patients need to undergo dialysis treatment. Therefore, high creatinine must be judged according to the specific value, and not a high value means that the kidney has been damaged very seriously. Another situation, such as acute renal failure with high creatinine, is that the kidney damage is serious, but the kidney can recover completely after treatment. Therefore, it is necessary to differentiate whether high creatinine is serious for kidney damage or not. High creatinine suggests kidney damage, and there are stages for the severity of kidney damage, such as for chronic renal failure, creatinine is divided into decompensated stage, compensated stage, renal failure stage, and uremic stage. Creatinine is a metabolic product of creatine, which exists in human muscles and also exogenous, such as protein that may produce creatinine after being metabolized by the body. Creatinine is mainly discharged from the body through glomerular filtration and is not reabsorbed in the renal tubules, so elevated blood creatinine is the content of the body’s muscle, for example, people with a stronger body and richer muscle creatinine may be slightly higher. At the same time, there are individual differences affected by dietary habits, such as the elderly, lean people, long-term vegetarians, although the creatinine is within the normal range, but kidney function has been reduced. Because creatinine reflects the muscle content of the human body, elderly people, thin people, and people who have been on a single diet for a long time may have a slightly lower creatinine in general. However, for these patients, although creatinine is also rising, but within the normal range, still need to pay attention to, may have kidney problems. Generally standard weight people will only have elevated creatinine when the glomerular filtration rate is below 50% of normal, for early stage such as declining kidney function, the change in blood creatinine will not be significant.