If creatinine is elevated, it is a big problem, because the kidney has a strong compensatory capacity, in the early stage of kidney damage creatinine does not appear elevated, when the glomerular filtration rate drops below 60ml/min blood creatinine will rise, if the blood creatinine is already elevated, suggesting that the kidney function is already in the case of moderate damage, if creatinine is elevated, to distinguish the causes of creatinine elevation If creatinine is elevated, the cause of the elevated creatinine should be identified. If it is due to fever or infection or a transient increase in creatinine caused by acute glomerulonephritis, it is not a big problem. The common causes of kidney failure include diabetic nephropathy, hypertensive nephropathy and chronic glomerulonephritis.