If the elevated creatinine is caused by acute kidney injury, it is more likely to come down. If the creatinine is elevated due to chronic renal failure, it is less likely to come down. Creatinine is an indicator of kidney function, elevated creatinine only indicates renal failure, but renal failure is divided into acute and chronic, the prognosis of the two is not the same. Acute renal failure is currently called acute kidney injury, mainly due to the application of a large number of nephrotoxic drugs in a short period of time, or caused by rhabdomyolysis. After the removal of these factors, after the maintenance of the kidneys, electrolyte balance and other treatments, the majority of patients are able to reduce creatinine and gradually return to normal kidney function. In contrast, chronic renal failure is caused by chronic kidney diseases, such as chronic nephritis, diabetic nephropathy, etc. Creatinine is gradually increasing, and these diseases cannot be reversed, so the possibility of creatinine coming down is very small.