Olanzapine and alcohol are two substances that do not interact with each other per se and do not cause disulfiram-like reactions similar to those occurring with cephalosporins and alcohol, but alcohol can aggravate the adverse effects of olanzapine and interfere with the drug efficacy of olanzapine, so drinking alcohol after taking olanzapine is not recommended. Olanzapine is a benzodiazepine antipsychotic drug clinically used to treat schizophrenia, manic episodes, and prevent relapse of bipolar disorder. The adverse effects of olanzapine are significant central nervous system depression, which induces limb weakness, drowsiness, dizziness, inability to sit still, gait abnormalities and dyskinesia. Alcohol has the same effect, and if both are used together it can cause a superposition of adverse reactions that can aggravate these symptoms, so it is recommended to avoid drinking alcohol after taking olanzapine.