Blood vessels are the richest tissues in our body, they are distributed in all parts of the body, and their structure and function are directly related to the function of the related organs. The blood vessels of the human body usually suffer from the internal impact of the blood flow and the influence of various components (lipids, blood sugar, uric acid stimulation), and from time to time they also have to be destroyed by external intravenous fluid components. An increasing number of studies have found that many diseases start in the endothelial cells of the blood vessels, which when stimulated can secrete a variety of cytokines that induce an inflammatory response and initiate the progression of chronic diseases such as atherosclerosis, hypertension, thrombotic diseases, and vasculitis syndromes. In addition, external factors (e.g., hypertension, local compression, psychological factors, etc.) can increase the tension of the entire blood vessel, which, over time, can cause vascular thickening and a series of pathophysiological damages to the blood supply organs. Nowadays, some diseases with genetic defects, such as polycystic kidney (nearly half of them are combined with hemangioma) and hereditary vascular developmental defects, are more and more common in clinical practice, which are not only related to the improvement of our diagnostic technology, but also to the acceleration of their lesions by environmental and dietary factors and bad habits. However, the impact of vascular disease on human health is generally not given enough attention in clinical practice, as reflected in the little attention paid to screening for vascular disease. Therefore, I would like to write an article to introduce this knowledge, hoping to draw your attention to it. The human blood vessels are a fragile part and need to be tested regularly. The structure of the medium and above human blood vessels is basically the same as the structure of the roadbed of a highway. In the case of small arteries, for example, the wall structure is divided into three layers: the inner, middle and outer membranes. The inner layer is the thinnest, with only one layer of cells, medically called endothelial cells, which are exposed to various components in the blood for a long time. In addition to being influenced by the rush-out force of blood flow, some special substances in the blood (macromolecular lipoproteins, blood sugar, uric acid, inflammatory mediators, various chemical drugs, photographic agents ….) can stimulate and initiate many pathophysiological reactions, some of which may trigger systemic pathologies (e.g. thrombosis, hypertension, cardiac and renal pathologies). The middle and outer layers of the vasculature, the muscular and elastin layers, respectively, maintain a constant pressure to maintain blood pressure and blood flow. Any trigger that leads to sustained high pressure, high flow and high perfusion of blood vessels (e.g. hypertension, local compression, vascular inflammation, etc.) can cause their thickening and elasticity to decrease, with the consequence of not only vessel thickening, narrowing, atherosclerosis, but also the possibility of inducing the production of aneurysms and rupture and bleeding ……. To make an inappropriate analogy, hyperlipidemia, hypertension, long-term intravenous infusion is like an overloaded dump truck running on the highway, the consequences are not difficult to imagine. Therefore, we should treat our blood vessels like maintaining highways with regular and long-term care, especially for high-risk groups with combined vascular lesions, such as those with long-term unhealthy lifestyles (smoking, unhealthy diet, lack of physical activity, heavy drinking, etc.), those with family history of cerebrovascular disease, those over 50 years old, those with combined hypertension, hyperglycemia, hyperlipidemia, obesity, carotid artery Patients with carotid artery stenosis and those with arrhythmia (atrial fibrillation) must be examined regularly for their cardiovascular structure and function. The reality is that the incidence of stroke in China is the highest in the Asia-Pacific region, with about 2 million new strokes each year, and the rate of increase is 8.7% per year, and the mortality rate is 4 to 5 times higher than in Europe and the United States. The former refers to cerebral infarction, carotid artery stenosis, vertebral artery stenosis and intracranial artery stenosis, which share a common pathological basis of atherosclerosis and have a progressive course, while the latter mainly includes cerebral hemorrhage, intracranial aneurysm and cerebrovascular malformation. Stroke, commonly known as “stroke”, is a “four-high” disease with high morbidity, mortality, disability and recurrence rates, and has become a worldwide problem that seriously affects human health. It should be noted that one of the common diseases among cerebrovascular diseases is intracranial aneurysm, which is characterized by aneurysm-like protrusion of blood vessels and thinning of blood vessel walls, so it is very easy to rupture and bleed. According to statistics, the annual incidence of cerebral hemangioma rupture and bleeding is about 9/100,000 people (the majority of unruptured aneurysms – UIA – do not rupture during their lifetime), and the mortality and disability rates are as high as 30%-45% and 50%. Its development is associated with congenital genetic factors (dysplasia of the vascular mesothelium) and later with atherosclerosis and hypertension. The risk factors for aneurysm development are not only related to the combination of hypertension, hyperlipidemia and atherosclerosis, but more importantly, they are closely related to his genetic background (family history of hemangioma), which are risk factors that cannot be intervened in later life, and only early screening and detection can avoid the risk.