What exactly does a marriage test detect? Is it important enough to affect the health of the next generation? What choice should we make? 1.Inquire about the history of genetic diseases Mainly for genetic diseases, including two major categories: monogenic genetic diseases and polygenic genetic diseases. 2.Physical examination The whole body and reproductive organs should be examined with the consent of both parties. For the examination of female reproductive organs, anal and abdominal wall double examination should be done, and if vaginal examination is needed, the consent of the patient or family members must be obtained. 3.Routine auxiliary examinations include chest X-ray, blood routine, urine routine, syphilis screening, transaminase and hepatitis B surface antigen detection, trichomonas and mycobacterial examination of female vaginal secretions, etc. 4, other special tests including hepatitis B serological marker test, gonorrhea, AIDS, mycoplasma and chlamydia examination, semen routine, ultrasound, breast, chromosome examination, etc., should be determined according to the need or voluntary principle. A normal premarital examination can reveal the presence of hereditary and infectious diseases in both parties and understand the pathogenic factors. Under the guidance of the doctor, the disease will be treated first, and then a decision will be made that is beneficial to both men and women and the next generation to reduce and avoid inappropriate marriages in order to reduce the birth of children with genetic diseases. Diseases affecting the quality of marriage 1. Genetic diseases include single gene diseases, polygenic diseases and chromosomal diseases. Single gene genetic disease: refers to a gene or a pair of corresponding gene abnormalities caused by the disorder, now found nearly 3600 kinds, because the cause of the disease gene single, so the genetic prevalence is high. Common diseases: red-green color blindness, high myopia, beta-thalassemia, congenital mental retardation, polydactyly, congenital deafness, congenital cataract. Congenital glaucoma, congenital ocular tissue defects, retinitis pigmentosa, retinoblastoma, albinism, hemophilia, Marfan syndrome, progressive myotonic dystrophy. Anti-vitamin D rickets, hepatomegaly, neurofibromas, etc. Polygenic genetic disorders: genetic traits are influenced by more than 2 pairs of genes, but each pair has no dominant or recessive relationship with each other, and these genes have weak but cumulative potency. Because of the plurality of causative genes, the chance of disease is low. Common disorders: congenital hip dislocation, cleft lip and palate, spina bifida, anencephaly, congenital clubfoot, congenital heart disease, hypertension, coronary artery disease, asthma, diabetes, schizophrenia, primary epilepsy, depression, etc. Chromosomal disorders: These are disorders that occur due to abnormalities in the number or structure of chromosomes. Chromosomal number abnormalities are more common than structural abnormalities. Common disorders: Down syndrome, whose chromosomal abnormalities are in trisomy 21, the main karyotype is trisomy, and a few are translocation or chimerism. 2.Infectious diseases Mainly various kinds of hepatitis, including hepatitis A, B, C, E, etc., and tuberculosis, etc. 3, sexually transmitted diseases are infectious diseases, including syphilis, gonorrhea, non-gonococcal urethritis and AIDS, etc. The most important examination before marriage is the routine semen examination of men, the semen routine examination can reflect the quantity, quality and motility of male sperm, which is an important observation indicator of conception, in addition to seminal plasma life, pathogenic microorganisms in semen, semen antibody examination are all vital, clinical examination is often carried out as needed to find out where the problem lies.