1, rheumatoid arthritis overview and the main symptoms rheumatoid arthritis (RA), is a chronic, mainly characterized by the invasion of joints, involving the whole body autoimmune disease. The prevalence in China is 0.35-0.4%, and the incidence is higher in women than in men, with a high incidence at the age of 40-50. It has a long course and high disability rate, and is an immune disease with high treatment difficulty. Its pathogenesis is unknown, and it is generally believed to be related to genetic (e.g. HLA-DR1, 4, etc.), infections, endocrine abnormalities, and other factors. The basic pathological change of rheumatoid arthritis is synovial inflammatory reaction, and this is the main reason why patients feel joint pain and joint effusion. The characteristic manifestations of rheumatoid arthritis are mainly the following four points: (1) symmetrical, multiple joint pains (more common in hands); (2) morning stiffness (greater than 1 hour); (3) rheumatoid nodules; and (4) a chronic wave-like progressive course that can eventually lead to joint deformity (this is the main cause of eventual disability). Its diagnosis mainly relies on clinical manifestations, laboratory tests and radiological examinations to confirm the diagnosis. If the above symptoms appear and persist for more than 6 weeks, especially when symmetrical multi-joint pain occurs and obvious triggers such as trauma are excluded, timely hospital examination is required for early detection and treatment to control disease progression and reduce the disability rate. 2, the treatment of rheumatoid arthritis rheumatoid arthritis is not yet a cure, the purpose of treatment is to control symptoms, prevent structural damage, restore physical function and improve the ability of daily life, and maximize the quality of health-related survival. The most important way to achieve treatment goals is to eliminate inflammation, emphasizing the principles of early treatment, combination of drugs and individualized therapy. In the early stage of the disease, non-surgical treatment is the mainstay. Patients should first establish the belief of long-term struggle with the disease and avoid various triggering factors. Appropriate rest, physical therapy, body therapy, proper joint activities and muscle exercises are useful in relieving symptoms and improving joint function, which should be carried out under the guidance of a physician. (1) Non-steroidal anti-inflammatory drugs: they have the function of anti-inflammation, pain relief and reduction of joint swelling. However, there is a need to pay attention to their gastrointestinal reactions and potential increase in cardiovascular risk (especially in the elderly), and not to take two NSAIDs at the same time. Although it can reduce symptoms, but can not change the course of the disease and joint destruction, other drugs need to be used in combination. (2) Anti-rheumatic drugs: These drugs are slower to work than NSAIDs, taking about 1 to 6 months. Does not have obvious analgesic and anti-inflammatory effects, but can slow down or control the progress of the disease. Commonly used drugs include salbutamol and methotrexate. To compensate for its slow onset and weak anti-inflammatory effect, it can be used in combination with a non-steroidal anti-inflammatory drugs. (3) Glucocorticosteroids: glucocorticosteroids can not stop the progress of the disease, and the adverse reactions are large, generally do not recommend long-term oral or intravenous treatment, only when the disease is serious short-term use. (4) Biological agents: A new type of drug for controlling RA, with good anti-inflammatory and stopping disease progression, commonly used drugs are etanercept, infliximab, adalimumab. Compared with traditional anti-rheumatic drugs, the main features of biologics for RA treatment are rapid onset of action, good overall patient tolerability, and significant efficacy in delaying or inhibiting bone destruction. Early application may lead to relief of clinical symptoms and somatic dysfunction and halt imaging progression in more patients with RA. However, it has the potential for injection site reactions or infusion reactions and an increased risk of tuberculosis infection, hepatitis virus activation, and tumors. Surgical treatment: When the disease progresses to severe joint pain, restricted movement or joint deformity, the effect of drug treatment is no longer effective and surgical treatment is required. (1) Synovectomy: If the disease is early and mainly involves large joints, arthroscopic synovectomy is feasible to relieve pain and swelling and delay cartilage destruction. (2) Arthroplasty: In the middle and late stages of the disease, especially when there is serious joint destruction and deformity, arthroplasty treatment is feasible. Especially if the ipsilateral hip or ankle and the contralateral knee, hip or ankle are involved, total arthroplasty can make the joint pain disappear, deformity correct and function improve. (3) Joint fusion: generally used as a salvage measure for failed arthroplasty. For small joint lesions, non-central joints or joints with low mobility requirements, it is applied when joint stability is required or when arthroplasty is not effective. In conclusion, although there is no cure for RA, early detection and treatment can effectively control the disease and reduce the disability rate. Even if the disease has progressed to the end stage, there are long-term developments in joint replacement technology, and after surgical treatment, most patients can significantly reduce pain and improve quality of life and joint function.