Herpes is categorized into herpes simplex and herpes zoster herpes, and herpes on toes can be treated with the appropriate medications according to the different diseases. 1. Herpes simplex: caused by the herpes simplex virus (HSV), clinically characterized by clustered blisters, self-limiting, can be used externally with antiviral drugs such as acyclovir ointment, penciclovir cream, or glycerite lotion; secondary infection can be used externally with antibiotics, such as fusidic acid cream, mupirocin ointment. 2. Herpes zoster: caused by varicella zoster virus (VZV), often first appeared erythema, soon appeared corn grain to soybean papules, cluster distribution without fusion, followed by rapid change into blisters, neuralgia is one of the characteristics of this disease, oral antiviral drugs such as acyclovir, vaxilovir, etc. treatment. Herpes on toes, it is recommended that patients seek medical attention in a timely manner, under the guidance of the doctor to use medication, do not blindly self-medication.