Scleroderma is not necessarily treated with glucocorticoids. Scleroderma is a connective tissue disease that involves multiple systems of the patient, divided into limited scleroderma and systemic scleroderma, limited scleroderma patients are mainly manifested as hardening of the skin, systemic scleroderma in addition to skin invasion can also involve multiple systems, multiple organs, limited scleroderma treatment to skin lesions with injections or topical glucocorticosteroids are mainly used. Systemic sclerosis main therapeutic measures for drug treatment, glucocorticoids can be used for patients with rapid disease progression and obvious inflammatory damage, commonly used drugs also include morphine maxolol ester, methotrexate, tolazoline, mosapride, nifedipine, aspirin and so on. The specific treatment plan for patients should be individualized by professional physicians according to the patient’s condition, and it is recommended that patients go to the rheumatology and immunology department of regular hospitals for consultation and treatment according to the doctor’s instructions.