Platelets in the maturation process gradually decompose, the volume decreases, large platelet ratio is high indicates the increase of large platelets, that is, platelet maturation disorder.1, large platelet ratio is mildly increased, mostly no special significance, can continue to observe, if there is no obvious change after a period of time, can not be dealt with.2, a small number of patients with large platelet ratio is high, especially the patients with significant increase, suggesting that suffering from certain diseases A few patients with high platelet ratio, especially those with markedly elevated platelet ratio, suggest that they are suffering from certain diseases, which may cause platelet maturation disorder, such as primary thrombocythemia, megakaryocytic leukemia, etc. It is recommended that the patients should undergo bone marrow aspiration as soon as possible for a clear diagnosis.