Botox injections for wrinkle removal belong to the category of medical beauty, and need to go to professional medical beauty institutions or hospitals for injections, not blindly in life beauty institutions for injections. If the operator is not a professional physician, incorrect mastery of the injection site and level in the injection process may lead to facial stiffness, subcutaneous bulging, allergic poisoning, and weakness of eye opening after injection. In addition, if the injection process is carried out in an irregular institution, it may lead to swelling, pain or infection because the sterilization work is not in place and the aseptic operation is not strictly followed. Therefore, when choosing to inject botulinum toxin for wrinkle removal, you first need to determine whether you are choosing a regular medical beauty institution as well as a professional doctor. Secondly, it is necessary to determine whether the drug is allowed to be used by the state and the source, so that we can guarantee the safety and effect of the injection. At present, China’s approval allows the use of botulinum toxin only the United States imported BOTOX and the domestic Lanzhou Hengli two brands of botulinum toxin, other brands of botulinum toxin are not approved by the Food and Drug Administration.