In the case of chronic lymphocytic leukemia, treatment may be withheld when no treatment is indicated. Treatment can be started if the lymphocyte doubling time is too fast and hemoglobin and platelets are gradually decreasing. 1. Chronic lymphocytic leukemia is treated when there is anemia, thrombocytopenia, or a large lymph node compressing the airways or organs and causing symptoms. Patients with chronic lymphocytic leukemia can be treated with drugs such as nitrogen mustard phenylbutyrate and ibrutinib as prescribed by the doctor, as well as interferon for immunotherapy, and hematopoietic stem cell transplantation can also be used for some patients with chronic lymphocytic leukemia. 2. If the patient does not meet the treatment indications, regular observation and monitoring are usually sufficient, and drug treatment is not necessary. Chronic lymphocytic leukemia is a malignant proliferative disease of hematopoietic stem cells in the blood system. The main manifestation is a marked increase in peripheral blood leukocytes, mainly lymphocytes. Most patients do not have specific clinical symptoms in the early stage and can have non-specific symptoms such as fatigue, weight loss, night sweats and so on. It is recommended that patients with chronic lymphocytic leukemia should be actively treated under doctor’s guidance, which can effectively improve the prognosis and prolong the survival period.