Second ejaculation in medicine is called premature ejaculation, in clinical medicine for the treatment of premature ejaculation there are many drugs, such as dapoxetine, sertraline hydrochloride, fluoxetine, etc., mainly to reduce the patient’s cerebral cortex excitability as well as the sensitivity of the glans mainly. 1. Dapoxetine: this kind of drug can reduce the sensitivity of the glans and the cerebral cortex, so as to prolong the patient’s sexual life time. 2. Sertraline hydrochloride: Sertraline can also reduce the sensitivity of the patient’s glans and reduce the sensitivity of the nerve endings in the penis, which can effectively improve the situation of second ejaculation. 3. Fluoxetine: After taking it, patients can reduce the sensitivity of the central nervous system, thus delaying ejaculation. It is worth noting that premature ejaculation is divided into physiological and pathological, it is recommended to go to the regular hospital for diagnosis, and under the guidance of the doctor for medication, do not blindly buy and take, otherwise it may cause irreversible damage to the body.