The normal value of indirect bilirubin is 1.7-10.2 μmol/L. Indirect bilirubin of 21.6 μmol/L is abnormal, which is two times higher than the normal value, and the specific severity of the disease needs to be considered in conjunction with the cause of the disease, which can not be accurately judged based on this indicator alone. Elevated indirect bilirubin may be caused by primary liver diseases, bile duct system problems and hemolytic jaundice, which need to be treated actively. 1. Primary liver diseases: For example, hepatitis causes damage to liver cells, resulting in bile metabolism disorders and elevated indirect bilirubin. 2. Bile duct system problems: for example, bile duct blockage will lead to bile excretion obstacles, bilirubin into the blood, can also cause indirect bilirubin elevation. 3. Hemolytic jaundice: a large number of red blood cells are destroyed and release hemoglobin, which is metabolized and converted into indirect bilirubin, thus indirect bilirubin is elevated. Therefore, it is recommended that patients go to regular hospitals as soon as possible to clarify the cause and receive further treatment.