The mechanism of the small nucleic acid spot removal method is to use nucleic acid interference technology to remove spots at source. The process of blemish removal is to apply such products on the face and then the small nucleic acids penetrate deep into the skin, encounter the melanocytes, reach the basal layer, control the melanin gene activity and inhibit the overproduction of melanin. This method is also safer because it does not require injection into the skin. However, the effect of each product varies from person to person. If a candidate is allergic, the use of micronucleic acid to remove blemishes may lead to facial allergy, which may cause mild peeling, itching and red spots on the face in mild cases, and in severe cases, it may cause large red spots on the face, swelling, eyelid edema, and even oozing and blistering, mostly accompanied by obvious itching discomfort. If you encounter this situation, it is recommended that you stop using it and then go to the hospital immediately. Pigmentation is a kind of pigmented skin disease, common pigmentation such as freckles, chloasma and so on. Its causes are mainly related to genetics, ultraviolet radiation, hormone level changes in the body, endocrine disorders, chronic liver and kidney diseases, gynecological diseases and oral contraceptives. Different types of pigmentation treatment methods are different. It is recommended that beauty seekers go to a regular hospital for consultation to clarify the types of pigmentation and take regular spot removal methods under the guidance of physicians.