Pancreatic occupancy is a diagnostic imaging term meaning that there is an occupying lesion in the pancreas, which may be inflammatory, neoplastic, and ectopic tissue, and other tests should be performed to clarify the diagnosis of the disease. Common inflammatory pancreatic occupying lesions include mass-type chronic pancreatitis, pancreatic pseudocysts, etc. Pancreatic neoplastic occupying lesions include islet cell tumors, pancreatic cancers, etc. Pancreatic ectopic tissues such as intrapancreatic paraspleens and limited lipoatrophy may be reported on the imaging report of pancreatic occupying lesions. In order to make a clear diagnosis, patients also need to follow the doctor’s instructions to improve other related examinations, such as abdominal enhanced CT, blood routine, blood biochemistry, tumor marker test, tissue biopsy, etc., generally can clarify the type of lesion. Patients with pancreatic space-occupying lesions should clarify the lesions under the guidance of the doctor and follow the doctor’s instructions to carry out appropriate treatment in a timely manner, so as to avoid further development of the condition, which may jeopardize the patient’s health.