Hepatitis B anti-interferon treatment standard is mainly for chronic prolonged hepatitis, chronic active hepatitis, serum free iron is in low level status, liver biopsy has active inflammatory lesions. 1. Chronic pre-delayed hepatitis: the aminotransferases of these patients with hepatitis B virus may be 150~200 units, and it is necessary to produce more antiviral proteins through the use of interferon in order to facilitate a better immune response and achieve the purpose of clearing the virus. 2. Chronic active hepatitis: it means that the hepatitis B virus is active at present, and the activity of the virus is relatively large, so it is necessary to use interferon to control the virus as soon as possible. 3. Serum free iron at low level: when the serum free iron level is low, the serum free iron needs to be used to antagonize interferon to control the virus. 4. Liver biopsy with active inflammatory lesions: such as crumbly necrosis, need to use interferon as soon as possible to control the progress of the disease. Hepatitis B virus patients should be aware of the use of interferon, if there is a history of psychiatric disorders or uncontrolled epilepsy, decompensated cirrhosis need to be prohibited, allergic to the drug components are prohibited, for children, pregnancy, and lactation need to be used with caution. Long-term use of interferon may produce adverse reactions, such as chills, fever, gastrointestinal discomfort, etc., the drug should be stopped immediately and seek medical attention. If patients with hepatitis B virus need to use interferon for a long period of time, they must be under the guidance of a professional physician to avoid unauthorized use of the drug.