Dry syndrome is somewhat hereditary. Patients with a family history of dry syndrome have a higher risk of developing the disease than the normal population. Studies at the genetic level have shown that the HLA-DRB1, DQA1, and DQB1 genes have the strongest correlation with susceptibility to the development of desiccation syndrome. In addition, patients with dry syndrome are positive for anti-SSA and anti-SSB antibodies on autoantibody testing. Antibody-positive pregnant women may pass antibodies to their fetuses through the placenta. The onset of dry syndrome is insidious, and patients may only have symptoms such as dry mouth, dry eyes, dry skin, dry tongue and muscle pain in the early stage. Patients with a family history of dry syndrome need to seek medical treatment as soon as possible once the above symptoms appear. It is recommended that patients with dry syndrome go to the rheumatology and immunology department of regular hospitals for detailed consultation and standardized treatment according to the doctor’s instructions.