Sabubatril full name Sacubatril Valsartan is not used readily may be the subject of the drug belongs to the group of people who need to be careful in the use of the drug, or has ever had an adverse reaction in the use of the drug. Sacubitril valsartan is mainly used for the treatment of cardiac function NYHA classification II to IV chronic heart failure and other diseases. Careful assessment of compliance with indications and exclusion of contraindications is required prior to use. The presence of contraindications also needs to be monitored during administration. In the case of sacubitril valsartan, there is no absolute contraindication to moderate renal insufficiency, moderate hepatic insufficiency, cardiac function NYHA class IV, etc., but it needs to be used with caution. In addition, if angioedema, hypotension, renal impairment, hyperkalemia, etc. occur during the use of the drug, it is also necessary to use the drug with caution, and if necessary, it is necessary to stop or change the drug. The drug is contraindicated in cases of drug allergy, the use of angiotensin-converting enzyme inhibitors, the presence of angioedema, the use of nosyntropin with aliskiren, severe hepatic insufficiency, biliary cirrhosis, cholestasis, mid- to late-stage pregnancy sufferers, breastfeeding. Sabubatril is recommended for use under the supervision of a clinician.