Uric acid 500μmol / L is not kidney failure, is considered hyperuricemia. The normal value of uric acid is 150~416μmol/L for men; 89~357μmol/l for women, and the specific reference standard is in accordance with the local hospital. Elevated uric acid may be caused by impaired excretion of uric acid after impaired renal function, or primary hyperuricemia. The main indicators for assessing renal failure are blood creatinine and glomerular filtration rate. Uric acid is the end product of purine catabolism and is excreted by the kidneys in the urine. If the blood uric acid is elevated and the blood creatinine is normal, then it is considered to be hyperuricemia, and uric acid-lowering drugs can be used in combination with specific conditions, such as febuxostat, allopurinol, benzbromarone and so on. If the blood uric acid is elevated, accompanied by elevated creatinine, it is necessary to consider the possibility of renal failure, we need to ask about the medical history, improve the urinary protein, urine routine, renal function and other tests, and if necessary, carry out renal puncture biopsy, to clarify the cause of the disease, and to assist in the diagnosis and treatment. The above medication should be used in accordance with the doctor’s prescription, and should not be used without authorization. Uric acid 500μmol / L suggests that the patient timely regular hospital consultation, under the guidance of the physician standardized treatment.