Oral vasodilators are the most important class of oral medications used to treat peripheral vascular disease. This is because most peripheral vascular diseases are caused by peripheral circulation disorders following vascular occlusion. Improving the blood circulation in the limbs and dilating the blood vessels becomes the common treatment principle. The main common oral vasodilators in clinical practice are phentolamine, which can directly dilate small arteries and capillaries and is mainly used in arterial spasm diseases of the extremities, thrombotic vasculitis, etc. Phenylpropanolamine, which has a better vasodilating effect on skeletal muscle and the strongest dilating effect on skin vessels, therefore has good efficacy in the treatment of terminal arteriosclerosis, arterial embolism and thrombosis, etc. Prostaglandins, most commonly used clinically, are prostaglandins, represented by cilostazol and beraprost sodium, which have a strong vasodilating effect and are one of the most commonly used oral vasodilating drugs for the treatment of peripheral arterial and venous disease in clinical and medical practice. In addition to the vasodilating drug effect, it also has an anti-platelet aggregation effect, so this type of drug is more widely used.