In the most severe cases of gray nails, treatment should be oral combined with topical antifungal medications, which can shorten the course of the disease and increase the efficacy. Patients can take oral antifungal drugs such as terbinafine, itraconazole, fluconazole, etc., but of course the duration of the disease will be longer, while the topical application of glacial acetic acid or soaking the diseased nail, the duration of the disease is also longer, or you can apply urea ointment wraps and then remove the diseased nail. Of course, topical application of amorolfine also has some effect. In short, the treatment period for nail fungus, or onychomycosis, can be quite long, and many patients have recurrent attacks, so you must be patient and adhere to the medication during its use. In addition, it is important to review liver function within a period of time after the application of antifungal oral medication, and if liver function is abnormal, the medication should be discontinued immediately.