In general, bifidobacteria are not harmful to the spleen and stomach, and their main action is in the intestines. Bifidobacterium bifidum may lead to intestinal flora imbalance and affect the normal immune function of the harm and so on. 1. Lead to intestinal flora imbalance: Bifidobacterium can regulate the intestinal flora, make the imbalance of the flora to achieve balance, usually used in the case of diarrhea. However, Bifidobacterium is only suitable for short-term use, if it is used for a long time, it may lead to the intestinal flora dependence on it, once stop taking Bifidobacterium, it will appear the state of dysbiosis, which is not conducive to the treatment of the disease. 2. Influence the normal immune function: long-term use of bifidobacteria to regulate the intestinal tract for too long, reducing the body’s own ability to regulate its own possession, affecting the normal immune function. After stopping taking it, instead, it may be more susceptible to bacterial infection, increasing the probability of contracting the disease. Bifidobacterium belongs to a kind of live bacterial preparation, and its way of taking should be under the guidance of physicians to avoid taking it by oneself, which is harmful to the body.