Leptospira belongs to a type of spirochete that can cause leptospirosis presenting with fever, headache, malaise, and large lymph nodes. Leptospira can cause leptospirosis, referred to as leptospirosis, an acute zoonotic infectious disease. Leptospira belongs to a type of spirochete and can cause systemic infection. Clinical symptoms are similar to a cold in the early stages, and in the later stages there may be damage to the liver, kidney, central nervous system, and a small number of patients may cause death. Leptospirosis is mainly transmitted by rodents and pigs, and its feces are discharged into the environment, which can be infected through the skin and mucous membranes. Clinically, fever, gastrocnemius pain, dizziness, headache, malaise, enlarged lymph nodes, and hemorrhage of organs may occur. Prompt medical attention is required when leptospirosis infection is detected.