Diabetes mellitus is the most common cause of endocrine erectile dysfunction. Whether it is type 1 diabetes or type 2 diabetes, erectile dysfunction is one of the common complications of diabetic patients, and even the first symptom of some diabetic patients. In China, the overall prevalence of diabetes among people over 20 years old is 9.7%, from which it is projected that the total number of diabetes patients in the country is about 92 million. Worse still, the prevalence of pre-diabetes is already as high as 15.5%, which is projected to be about 148 million pre-diabetics nationwide. Erectile dysfunction caused by diabetes mellitus is called diabetic erectile dysfunction, and its incidence accounts for 30-75% of men with diabetes mellitus, which has a serious impact on the quality of life of patients, sexual partnership, and family stability. The prevalence and severity of diabetic erectile dysfunction are significantly related to age at the time of diabetes, duration of disease, type of diabetes, glycemic control, diabetic neuropathy, diabetic nephropathy and hypertension. The pathogenesis of the disease is very complex and not yet fully understood, involving various factors such as neurological, vascular, metabolic, endocrine and neurotransmitter factors, and there may be different mechanisms in different patients and at different stages of the disease. Detailed studies have shown that vascular and neuropathy account for 89% of diabetic patients with erectile dysfunction, and 39% of patients with both factors. In addition, psychological factors also play an important role in the development of diabetic erectile dysfunction. In conclusion, diabetes mellitus is one of the most important causes of erectile dysfunction. The treatment of this disease requires the first treatment of the primary disease, the blood sugar control in the normal range. Then through the Chinese and Western medicines after a longer period of treatment, can achieve better results.