Patients with chest pain on deep inhalation are considered to have pneumothorax, e.g., tension pneumothorax, traffic pneumothorax, and open pneumothorax, which can present with chest pain on deep inhalation. If the above situation occurs, it is necessary to go to the hospital immediately, complete the 18-lead electrocardiogram, and do the cardiac enzymology markers to exclude whether it is a cardiac source of factors, such as coronary atherosclerotic heart disease, unstable angina pectoris, and myocardial ischemia that causes chest pain when taking a deep breath. Chest radiographs and CT should also be taken to rule out pneumothorax. If it is caused by any of the above, surgical treatment is needed. If it is cardiogenic factors that lead to chest pain when neurological system, sublingual nitroglycerin, to see if the symptoms are relieved, if there is no obvious relief, and progressive pain, the emergence of obvious acute coronary syndrome, to consider intervention for treatment.