For patients with bacterial infections, both cephalosporin as well as amoxicillin are effective, as both are antibiotics for bacterial infections, but the effectiveness of taking them needs to be classified in relation to the specific bacterial classification of the patient’s infection. If the patient is suffering from a disease due to community-acquired pneumonia, usually due to a Gram-positive bacterial infection, in this case, treatment with amoxicillin as well as first-generation cephalosporins is effective. If the patient has a hospital-acquired infection caused by a Gram-negative bacterium, amoxicillin is less effective in this case because it is mainly effective in treating Gram-positive infections, so cephalosporin II or cephalosporin III may be considered for treatment in this case. If the patient has a serious bacterial infection, or even sepsis with Gram-negative bacilli, a fourth- or even fifth-generation cephalosporin drug is needed for effective anti-infection treatment. Therefore, the choice of antibiotics also needs to be analyzed and judged according to the specific antibacterial spectrum of the antibiotics and the classification of the pathogenic bacteria.