Chapter Note: According to the WHO Pathological Classification of Lymphatic System Tumors, there are nearly 70 pathological types of lymphoma, which are divided into two categories: Hodgkin’s lymphoma and non-Hodgkin’s lymphoma. In China, Hodgkin’s lymphoma accounts for 9%-10% of lymphoma and non-Hodgkin’s lymphoma accounts for about 90%. 80% or more of Hodgkin’s lymphoma can be cured and the treatment rate of non-Hodgkin’s lymphoma has reached 50-60%. Hodgkin’s lymphoma metastasizes in a sequential infiltrative fashion, whereas non-Hodgkin’s lymphoma metastases in a jumpy fashion. By biological characteristics, they can be classified as inert and aggressive. Different treatment strategies are recommended for different types of lymphoma. The low-risk group is treated with simple chemotherapy plus radiotherapy. High-risk groups and those with short-term relapse should be treated with high-dose chemotherapy combined with autologous hematopoietic stem cell transplantation. Meroval, CD30, lenalidomide and autologous LMP2 protein-specific CTL for recurrent EBV+ Hodgkin’s lymphoma show a brighter future. The name “Hodgkin’s lymphoma” comes from Thomas Hodgkin, who discovered this unique malignant disease of the lymphatic system in 1832 and named it after him. Hodgkin’s lymphoma is one of the most common malignancies in young people. It is characterized by painless, progressive enlargement of the lymph nodes in the neck, and 20% to 30% of patients present with fever, night sweats, and wasting . The latest WHO classification classifies Hodgkin’s lymphoma into nodular lymphocyte-dominant type and classic Hodgkin’s lymphoma. The histological subtype and clinical stage are the main factors in determining patient prognosis and choosing treatment options. For early stage patients, a combination of chemotherapy and radiotherapy can achieve a 10-year survival rate of 70% to 80%; for advanced stage patients, a stronger chemotherapy regimen, combined with radiotherapy if necessary, can still achieve a 10-year survival rate of 50% to 60%; for refractory patients, targeted therapy and hematopoietic stem cell transplantation can be chosen, which can also achieve good results. Thirty years ago, Dr. Zhang saw her first patient, Liang. He was diagnosed with Hodgkin’s lymphoma (mixed cell type) stage III. Dr. Zhang had full confidence in Ryo. Ryo was not intimidated by the disease either. He was brave and strong and always believed that he could beat the disease. Two confident people met on a special battlefield, destined for a miracle. The 8-cycle MOPP chemotherapy regimen + cape + inverted “Y” radiation therapy was chosen. After six months of hard work by the doctors and Ryo, Ryo recovered. When he was discharged from the hospital, the doctor kept advising him about the precautions to take after discharge and to return to the hospital for regular review. Two years later, he fell in love and subsequently had a happy marriage, which brought him a smart and intelligent daughter, who has long since gone abroad for further studies. Ryo has also become an entrepreneur and has done a lot of charity work that benefits the community. He also brings his friends and relatives to see Director Zhang from time to time, and he believes that he is the good doctor to trust. In the ward of Shanxi University Hospital, there lived a 35-year-old successful man who was diagnosed with Hodgkin’s lymphoma (nodular sclerosis type), and Director Zhang drew up 6 courses of ABVD protocol chemotherapy + local radiotherapy for him, and he was cured after half a year. During the treatment period, he drove himself to and from work every day and never stopped working. He often laughs and says to his patients that lymphoma is like curing a cold, miraculously cured. Dongdong, a lively 10-year-old boy, was unfortunately diagnosed with Hodgkin’s lymphoma when he was at the age of innocence. After going through many hospitals and 8 cycles of chemotherapy, he still had a high fever, low blood count, and a giant spleen, so his almost desperate mother found Director Zhang with a last ray of hope. After a unique treatment plan was developed for him, Dongdong was miraculously cured. He was finally able to return to the classroom of his dreams and to the children. Director Zhang’s words 1. Patients with lymphoma must go to a regular hospital and receive comprehensive treatment under the scientific diagnosis of a specialist. 2. The treatment of Hodgkin’s lymphoma is very challenging for doctors, and the precision of treatment plan and the appropriateness of treatment means are the gold standard to measure the level of doctors, and neither over-treatment nor inappropriate treatment is desirable. 3.The doctor’s superb technology comes from the accumulation of rich clinical experience and perception, and also depends on the patient’s cooperation and trust.