Adenomyosis is more effective after the use of leuprolide subcutaneous injection, which can lead to a significant reduction in the size of the uterus and a significant reduction in menstrual pain symptoms. However, it should not be used as a long-term treatment, but only as a pretreatment before surgery or assisted reproduction. After the uterus has shrunk, if the patient does not require surgery in the near future and does not need to have children, treatment with leucovorin is recommended. If the patient has a need for fertility in the near future, early pregnancy is recommended. Adenomyosis is a kind of endometriosis, which is a common and frequent disease. The typical clinical symptoms are secondary dysmenorrhea, progressive aggravation, accompanied by abnormal menstrual flow, and its treatment needs to be considered according to the patient’s age, fertility requirements and symptoms.