The precautions for tachyphylaxis are as follows: i. Water and electrolyte disturbances can occur with sedation because excessive diuresis can lead to hypovolemia, hypokalemia, hyponatremia, and hypochloremic alkalosis. In case of electrolyte disturbance, the drug should be administered by intermittent therapy, such as 1-3 days of medication and 2-4 days of discontinuation. Potassium supplementation should be routinely administered and diluted for slow sedation, and electrolyte concentration in blood should also be routinely checked. Gastrointestinal reactions are often observed during sedation, which may include nausea, vomiting, diarrhea, epigastric pain and even gastrointestinal bleeding. Occasionally, cardiac arrhythmia, rash, liver damage, granulocyte deficiency, hepatic coma may occur in patients with hepatitis, and increased blood sugar in diabetic patients. 4. Ototoxicosis can also occur, manifested as tinnitus and vertigo, and hearing loss can be caused by high-dose sedation. Fifth, it can also cause hyperuricemia. 6. Combination with aminoglycoside antibiotics should be avoided to prevent increased ototoxicity. Avoid combining with ceftazidime to prevent increased nephrotoxicity. Pregnant women, nursing mothers and patients with severe heart failure, renal failure, hypotension and hepatic coma are prohibited.