Ultrasound in the 6th month of pregnancy suggests fetal polycystic kidney, amniocentesis should be done for further examination to clarify whether the fetus has chromosomal abnormality. Fetal polycystic kidney is a kind of chromosomal recessive genetic disease, which usually has a family history, in addition, prolonged exposure to severely polluted environments, toxic chemicals, rays, etc. may also lead to the development of polycystic kidney in the fetus. When obstetric ultrasound suggests polycystic kidney, amniocentesis should be done to rule out whether the fetus has chromosomal abnormalities. If there are chromosomal abnormalities or other malformations present, it is recommended to take the next step under the guidance of obstetricians. Women are advised to avoid exposure to toxic and harmful substances during preparation for and during pregnancy, to undergo regular obstetric examinations, and to consult their obstetrician promptly if there are any abnormalities in the course of the obstetric examination.