The uncomfortable, indescribable feeling in the calves at night is most likely restless leg syndrome. Restless legs syndrome can be manifested as various discomfort sensations in both lower extremities at night during sleep, or in a quiet state, such as itching, burning, tearing, and pain, more pronounced in the lower legs, which will force the patient to keep walking on the floor, which will be very obvious at night, and 80% of them are accompanied by periodic leg movements, which will affect the patient’s sleep, lead to depression as well as blood pressure fluctuations, and affect the quality of life. Secondary causes of restless legs syndrome include hormonal changes, iron deficiency, etc. Serum iron and ferritin tests, as well as blood tests, liver and kidney function tests, and hormone tests can be done to further search for secondary causes.