There are usually several reasons for the calf pain at night: 1, such as excessive exercise, the body will produce anaerobic glycolysis to start the glycoisomeric pathway and metabolize too much lactic acid, which will accumulate in the skeletal muscle and cause the symptoms of calf pain at night; 2, such as incorrect exercise methods or exercise one-time too much will lead to rhabdomyolysis, such as anaerobic exercise continues to deepen will cause creatine kinase in the body 3, such as exercise at night before going to bed without stretching or trauma, such as leg impact, etc. will also have difficulty sleeping calves; 4, in the high temperature environment there is heat stroke will also have difficulty sleeping calves symptoms; 5, endocrine metabolic diseases and rare diseases, such as ion disorders, periodic hypokalemia or hyponatremia will also have The symptom of uncomfortable calves at night while sleeping.