Splenomegaly does not usually recover on its own without treatment. Common causes of splenomegaly include hepatitis, cirrhosis, cornual tuberculosis, typhoid fever, leukemia, and heart failure, etc. These diseases usually do not heal on their own, so splenomegaly does not recover on its own. The spleen is an important lymphatic organ in the body, which stores blood, produces lymphocytes, and filters germs, antigens, foreign bodies, and protozoa from the blood, serving an immune function. For example, when the virus stimulates the spleen in hepatitis B, it causes the spleen to become congested and enlarged; in cirrhosis or heart failure, the body’s blood circulation is not smooth and the pressure in the splenic vein increases, resulting in a large spleen and hypersplenism. In case of early cirrhosis or acute hepatitis patients, the enlarged spleen may return to normal after treatment, but in case of advanced cirrhosis or chronic hepatitis patients, it is difficult for the enlarged spleen to return to normal completely even after treatment. Therefore, splenomegaly will not recover on its own without treatment. It is recommended that patients with a large spleen should go to the appropriate hospital department for treatment in a timely manner, such as gastroenterology and hematology. Also, patients should pay attention in their daily life, not to smoke or drink anymore, and avoid too strenuous exercise.