Patients with coronary artery disease need to undergo interventional treatment, and it is important to select the right patient and seize the right time. In most patients with coronary artery disease, the main pathological basis is atherosclerosis of the coronary arteries. With the further aggravation of the lesion, the atheromatous plaque will occupy enough lumen area of the coronary artery to cause blood flow restriction, which will manifest clinically as ischemia-related symptoms, such as angina pectoris, arrhythmia or cardiac insufficiency. In the other case, the plaque is not large enough, but it is unstable and prone to rupture, which can lead to some thrombotic events, affecting and restricting the antegrade blood flow, which can also manifest clinically as ischemia-related symptoms or even adverse cardiac events, such as acute myocardial infarction. Thus, it is particularly important to curb the development of atheroma and maintain the stable state of the plaque, and there is a solid clinical basis for therapeutic measures in this area, such as active intervention in unhealthy lifestyles (smoking, alcohol abuse, lack of exercise, too little fruit and vegetable intake, etc.); pharmacological control of reversible risk factors for coronary artery disease (hypertension, dyslipidemia, diabetes), which can reduce the The incidence of coronary heart disease can be reduced by controlling the reversible risk factors of coronary heart disease (hypertension, dyslipidemia, diabetes mellitus); stabilizing the plaque by long-term statin lipid-regulating drugs and antiplatelet therapy; improving the heart function by treating the over-activation of neurohumoral endocrine mechanisms. Therefore, we say that primary and secondary prevention treatment for coronary heart disease is important. So, which patients need interventional treatment? In my opinion, patients with sudden acute cardiac events, such as patients with myocardial infarction and patients with frequent episodes of angina pectoris during drug treatment, should undergo coronary angiography as early as possible to evaluate the lesions of coronary arteries, and if intervention is feasible, to accurately target the vessels related to the infarction and the “criminal” vessels of angina pectoris. The So how is this early defined? In patients with acute myocardial infarction, the sooner the vessel is opened, the better. The general time window is within 12 hours of onset, and if the patient still has chest pain or hemodynamic abnormalities after 12 hours, an angiogram can be performed experimentally to open the vessel as much as possible. The time window for early intervention in patients with unstable angina is 48 hours after onset, provided that the angina is not controlled by reasonable and adequate drug therapy or there is a clear basis for large area myocardial ischemia. While interventional techniques are important, tactical literacy must not be overlooked. The introduction of interventional technology is a revolution in the history of coronary heart disease treatment, and it is indisputable that interventional therapy has become an important means of treatment for patients with coronary heart disease, but it is also indisputable that not all patients who undergo interventional therapy can benefit from it. I believe that patients who are expected to undergo interventional therapy must have a thorough review of their clinical condition. For example, the presence of other diseases, the function of important organs, especially the response to the use of contrast agents and the volume limits, and the feasibility and safety of long-term postoperative use of antiplatelet agents. In other words, preoperative patient safety assessment and planning should be done. The purpose is clear: to make the procedure safer and more reliable, and not to limit or affect the treatment of other diseases because of the procedure. When performing interventions, the extent of the lesion on coronary angiography should not be the only indicator of intervention, but rather the benefit and risk to the patient after the intervention. Because intervention-related adverse events, such as in-stent thrombotic events and restenosis, can still occur after intervention, the choice to perform intervention for multiple vascular lesions can be done in stages, addressing the lesions that are closely related to symptoms first, following the patient under strict pharmacological treatment, and then reviewing the angiogram if necessary to decide on further therapeutic measures. The treatment of coronary artery disease is a three-dimensional battle of attack and must be strategic. The treatment of coronary heart disease includes reasonable drug therapy, timely interventional therapy and coronary artery bypass graft surgery. Drug therapy is the basic treatment; interventional therapy is convenient, less invasive and faster recovery; surgical treatment can be close to complete hemodynamic reconstruction treatment, these three treatment means are not isolated, each has its own merits and often complement each other. In patients with coronary artery disease treated with medications, the choice between interventional or surgical treatment must take into account its long-term efficacy while ensuring the safety of the procedure. In patients with sudden cardiovascular events, such as acute myocardial infarction, interventional treatment should be performed as soon as possible to open the infarct-related vessels. Whether interventional or surgical treatment is performed, postoperative drugs for secondary prevention of coronary heart disease are indispensable, and attention should also be paid to patient management.