High glutamate dehydrogenase indicates liver cell damage, and elevated glutamyl transpeptidase also indicates liver disease, with different degrees of elevation representing different diseases. Glutamate dehydrogenase is a mitochondrial enzyme mainly found in the liver, heart and kidney. γ-Glutamyl transpeptidase is widely distributed in all tissues of the body, and the γ-GT in the serum of normal people mainly comes from the liver. Clinically, these two enzymes are mainly used for the diagnosis of hepatobiliary diseases. 1. Abnormal elevation of glutamate dehydrogenase: It indicates that acute viral hepatitis, chronic hepatitis, cirrhosis and liver fibrosis may exist in the liver. Generally, the greater the degree of elevation, the more serious damage to the liver, the most sensitive in reflecting alcoholic hepatocellular injury, the specific disease should be combined with the patient’s physical condition under the guidance of the doctor’s diagnosis. 2. Elevated glutamine transpeptidase: Liver damage and alcohol consumption can cause elevated glutamine transpeptidase. Mild to moderate elevation indicates that the patient may have chronic active hepatitis, acute hepatitis or hepatic cirrhosis, etc. Significant elevation may have obstructive jaundice or primary liver cancer, which should be diagnosed under the guidance of the doctor in combination with the test results. Early symptoms of liver diseases are usually not obvious and hard to detect, you should maintain good living habits, drink less alcohol, stay up less late and pay attention to regular medical checkups to protect your liver.