Postoperative T2N0M0 of middle esophageal squamous carcinoma, chemotherapy regimen commonly used cisplatin+paclitaxel, most of the patients with postoperative chemotherapy treatment, the prognosis is better. Postoperative T2N0M0 of middle esophageal squamous carcinoma mainly refers to the situation that the tumor has invaded into the mucosa muscle layer, but there is no lymph node and distant metastasis. This kind of patients can take chemotherapy as prescribed by doctors, so as to kill the residual cancer cells, thus playing the role of assisting in controlling the development of the disease, and most of the patients have a better prognosis. Before chemotherapy, patients need to undergo blood routine, renal function, electrocardiogram and other tests in the first week, so as to clarify whether there are contraindications to chemotherapy. If there is no abnormality in heart, liver, kidney, and hematopoietic function, chemotherapy can be taken. Generally, patients can follow the doctor’s instructions for intravenous drip, and the commonly used chemotherapy program is cisplatin + paclitaxel. During the chemotherapy treatment, patients should follow the doctor’s instructions for regular review, in order to understand the recovery of the disease.