Weight gain after taking metformin may be caused by uncontrolled diet, lack of physical activity, etc. It may also be combined with diseases such as Cushing’s syndrome. Metformin is a glucose-lowering drug that can reduce hepatic glucose synthesis as well as reduce intestinal glucose absorption, and has a certain effect on weight loss in obese diabetics. However, if you do not pay attention to lifestyle intervention, diet control, overeating, lack of physical activity, etc., it may lead to weight gain triggering obesity. In addition, the combination of organic diseases, such as Cushing’s syndrome, can also lead to weight gain. When the sudden weight gain is obvious, it is necessary to consult a doctor in time, under the guidance of the doctor to clarify the cause of the disease and then carry out targeted treatment.