Taking anti-anxiety and depression drugs or waking up early, may be the individualized differences in the use of medication, the side effects of the drug or the drug has just begun to use the symptoms are not fully controlled. 1. Some of the anti-anxiety and depression drugs have side effects that cause insomnia, such as sertraline, resulting in early awakening even after using the drug. 2. The efficacy of the drug has individualized differences, the therapeutic effect is not completely consistent, the condition itself is also light and heavy, the need to develop individualized treatment plan. Some patients have just started to use the drug, the drug has not been fully effective, sleep symptoms have not been significantly improved. 3. If the antidepressant and anxiety drugs have just started to use, you can continue to take a period of time to observe the effect. If the continued use of drugs did not improve the short-term addition of benzodiazepines, such as alprazolam tablets, eszopiclone tablets, etc. to improve sleep, should be used under the guidance of the physician. Patients should usually relax their emotions, pay attention to relieving stress, and do not exert themselves. Anti-anxiety depression in the process of any discomfort need to consult a doctor in a timely manner, under the guidance of the physician’s treatment, do not self-medication.