Frank’s sign, also known as the earlobe fold sign, is associated with cardiovascular disease, particularly coronary artery disease. Frank’s sign is a specific manifestation of the earlobe, which in contrast to the normal earlobe can be characterized by a diagonal fold that extends from the ear screen to the auricle at a 45-degree angle. Frank’s sign is associated with cardiovascular disease and may be a reflection of coronary artery disease on the skin, which may help to predict atherosclerotic disease. Once Frank’s sign is present, the first step is to diagnose possible coronary artery disease and determine whether atherosclerosis is present. Once the diagnosis is confirmed, it is necessary to actively intervene in risk factors such as hypertension, hyperglycemia, obesity, etc., and actively correct poor lifestyles by reducing the intake of high-oil and high-fat foods, controlling the intake of sodium, and moderately increasing the intake of fresh vegetables. At the same time, it is necessary to pay attention to strengthen the exercise, quit smoking and drinking, and maintain emotional peace and stability.